Creative Biostructure is a biotechnology company offering drug discovery contract services to pharma, biotech, chemical companies, and academic institutes. Based on our zebrafish screening platform, we can provide MagHelix™ toxicity assays using zebrafish. Zebrafish has been a prominent model vertebrate for investigating chemical toxicity. We aim at developing new and faster screen/bioassays using zebrafish as an animal model, as well as new technologies for optimizing the maintenance and breeding of zebrafish.
Figure 1. Visualization of the zebrafish embryo vasculature by gfp:fli1 expressing endothelial cells.
|General Toxicity Assays
|Acute Toxicity Assay
|Following the OECD 236 Guideline (Fish Embryo Acute Toxicity Test), the test is to determine the acute or lethal toxicity of chemicals on embryonic stages of fish (Danio rerio).
|Reproductive/Developmental Toxicity Assay
|To understand the potential of a drug to induce birth defects in offspring; that is to detect toxicity to reproduction and/or male fertility for medicinal products.
|Specific Toxicity Assays
|Integrating of fluorescent reporter genes into the zebrafish model allows visualization of specific tissues, such as the heart.
|Mechanisms that occur during the process of development have been characterized, which helps the study of signaling pathways that govern zebrafish liver function.
|The zebrafish is used to fill the gaps between various in vitro and in vivo models currently being used to identify mechanisms of developmental neurotoxicity.
|Zebrafish lateral line has been proved as a powerful screening tool for the identification of potentially ototoxic drugs.
|Multi-organ Toxicity Assay
|High-throughput zebrafish screens are becoming an important tool in identifying compounds with potential three main (cardiac-, hepato- and neuro-) toxicity liabilities in the same animal.
Creative Biostructure provides high-value services for any organization with a need for zebrafish model development or drug toxicity evaluation. We have the ability to provide highly efficient and customized toxicity assays to meet your requirements.