Creative Biostructure is a biotechnology company offering drug discovery contract services to pharma, biotech, chemical companies, and academic institutes. Based on our zebrafish screening platform, we can provide MagHelix™ toxicity assays using zebrafish. Zebrafish has been a prominent model vertebrate for investigating chemical toxicity. We aim at developing new and faster screen/bioassays using zebrafish as an animal model, as well as new technologies for optimizing the maintenance and breeding of zebrafish.
Figure 1. Visualization of the zebrafish embryo vasculature by gfp:fli1 expressing endothelial cells.
| General Toxicity Assays | |
|---|---|
| Acute Toxicity Assay | Following the OECD 236 Guideline (Fish Embryo Acute Toxicity Test), the test is to determine the acute or lethal toxicity of chemicals on embryonic stages of fish (Danio rerio). |
| Reproductive/Developmental Toxicity Assay | To understand the potential of a drug to induce birth defects in offspring; that is to detect toxicity to reproduction and/or male fertility for medicinal products. |
| Specific Toxicity Assays | |
| Cardiotoxicity Assay | Integrating of fluorescent reporter genes into the zebrafish model allows visualization of specific tissues, such as the heart. |
| Hepatotoxicity Assay | Mechanisms that occur during the process of development have been characterized, which helps the study of signaling pathways that govern zebrafish liver function. |
| Neurotoxicity Assay | The zebrafish is used to fill the gaps between various in vitro and in vivo models currently being used to identify mechanisms of developmental neurotoxicity. |
| Ototoxicity Assay | Zebrafish lateral line has been proved as a powerful screening tool for the identification of potentially ototoxic drugs. |
| Multi-organ Toxicity Assay | High-throughput zebrafish screens are becoming an important tool in identifying compounds with potential three main (cardiac-, hepato- and neuro-) toxicity liabilities in the same animal. |
Creative Biostructure provides high-value services for any organization with a need for zebrafish model development or drug toxicity evaluation. We have the ability to provide highly efficient and customized toxicity assays to meet your requirements.
References
